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677288 
Journal Article 
Immunity, inflammation, and cancer 
Grivennikov, SI; Greten, FR; Karin, M 
2010 
Yes 
Cell
ISSN: 0092-8674
EISSN: 1097-4172 
140 
6 
883-899 
English 
WOS:000275746600012 
Inflammatory responses play decisive roles at different stages of tumor development, including initiation, promotion, malignant conversion, invasion, and metastasis. Inflammation also affects immune surveillance and responses to therapy. Immune cells that infiltrate tumors engage in an extensive and dynamic crosstalk with cancer cells, and some of the molecular events that mediate this dialog have been revealed. This review outlines the principal mechanisms that govern the effects of inflammation and immunity on tumor development and discusses attractive new targets for cancer therapy and prevention. 
Animals; Cell Transformation, Neoplastic/immunology; Humans; Immune System/cytology; Inflammation/immunology/*physiopathology; Neoplasms/*immunology