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688754 
Journal Article 
Alveoli increase in number but not size from birth to adulthood in rhesus monkeys 
Hyde, DM; Blozis, SA; Avdalovic, MV; Putney, LF; Dettorre, R; Quesenberry, NJ; Singh, P; Tyler, NK 
2007 
Yes 
American Journal of Physiology: Lung Cellular and Molecular Physiology
ISSN: 1040-0605
EISSN: 1522-1504 
293 
3 
L570-579 
English 
17586691 
WOS:000249125100011 
has comment/response 3348320 Developmental alveologenesis: Longer, differential regulation and perhaps more danger
Postnatal developmental stages of lung parenchyma in rhesus monkeys is about one-third that of humans. Alveoli in humans are reported to be formed up to 8 yr of age. We used design-based stereological methods to estimate the number of alveoli (N(alv)) in male and female rhesus monkeys over the first 7 yr of life. Twenty-six rhesus monkeys (13 males ranging in age from 4 to 1,920 days and lung volumes from 41.7 to 602 cm(3), 13 females ranging in age from 22 to 2,675 days and lung volumes from 43.5 to 380 cm(3)) were necropsied and lungs fixed, isotropically oriented, fractionated, sampled, embedded, and sectioned for alveolar counting. Parenchymal, alveolar, alveolar duct core air, and interalveolar septal tissue volumes increased rapidly during the first 2 yr with slowed growth from 2 to 7 yr. The rate of change was greater in males than females. N(alv) also showed consistent growth throughout the study, with increases in N(alv) best predicted by increases in lung volume. However, mean alveolar volume showed little relationship with age, lung volume, or body weight but was larger in females and showed a greater size distribution than in males. Alveoli increase in number but not volume throughout postnatal development in rhesus monkeys. 
stereology; parenchyma; alveolar ducts; postnatal development 
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