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708586 
Journal Article 
Chloral hydrate is recombinogenic in the wing spot test in Drosophila melanogaster 
Zordan, M; Osti, M; Pesce, M; Costa, R 
1994 
1 
Mutation Research
ISSN: 0027-5107
EISSN: 1873-135X 
322 
2 
111-116 
English 
7519317 
In order to characterise the response of the wing spot test in Drosophila melanogaster to the effects of compounds with known aneugenic properties, experiments were performed with chloral hydrate (CH). Following chronic exposure of 72-h-old larvae to rising concentrations of CH, significant increases in the frequency of small (1-2 cells) single spots were observed. Comparison of results obtained in parallel from the wings of marker-trans-heterozygous individuals and individuals heterozygous for one of two different balancer chromosomes suggests that practically all the single clones originated from recombinational events. Twin clone frequencies were, however, only weakly affected. These results are discussed with reference to the literature regarding the effects of CH in different experimental systems and to the characteristics of Drosophila as a tester organism.