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725545 
Book/Book Chapter 
Dichloromethane 
American Conference of Governmental Industrial Hygienists :: ACGIH 
2001 
American Conference of Governmental Industrial Hygienists 
Cincinnati, OH 
Documentation of the threshold limit values and biological exposure indices 
7th Ed 
D1 
English 
A TLV-TWA of 50 ppm (174 mg/m3) is recommended for occupational exposure to dichloromethane is part by analogy to the TLVs for trichloroethylene and the more potent CNS depressant, tetrachloroethylene. This value is intended to minimize the potential for elevation of carboxyhemoglobin and central nervous system (CNS) depression. Dichloromethane is considered a weak animal carcinogen based on liver and lung cancer in mice and benign mammary gland tumors in rats after chronic inhalation at high concentrations ( > = 1000 ppm). Accordingly, an A3, Confirmed Animal Carcinogen with Unknown Relevance to Humans, is assigned. Sufficient data were not available to recommend Skin or SEN notations or a TLV-STEL. Dichloromethane is a substance for which Biological Exposure Indices (BEIs) have been recommended (see BEI Documentation for Dichloromethane) 
11/06/2007