Chemicals associated with tumours of the kidney, urinary bladder and thyroid gland in laboratory rodents from 2000 US National Toxicology Program/National Cancer Institute bioassays for carcinogenicity | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

732741

Reference Type

Book/Book Chapter

Title

Chemicals associated with tumours of the kidney, urinary bladder and thyroid gland in laboratory rodents from 2000 US National Toxicology Program/National Cancer Institute bioassays for carcinogenicity

Author(s)

Huff, J

Year

1999

Publisher

International Agency for Research on Cancer

Location

Lyon, France

Book Title

Species differences in thyroid, kidney and urinary bladder carcinogenesis

Page Numbers

211-225

Language

English

PMID

10457919

Web of Science Id

WOS:000165216800014

Abstract

This publication originates from a workshop held in 1997 to consider how rodent tumours of urinary bladder, renal cortex, and thyroid gland should be treated within the IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. The workshop also addressed the predictive value of these tumours for the identification of carcinogenic hazards to humans when they occur alone and when they occur along with tumours in other organs. In the following sections, etiological risk factors in humans and experimental animals as well as the hypotheses underlying the proposed species-specific mechanisms for each of the above-mentioned tumour types are summarized. Finally, for each tumour type, recommendations are presented on how the mechanistic data could be used in the overall evaluation of carcinogenicity to humans.

Editor(s)

Capen, CC; Dybing, E; Rice, JM; Wilbourn, JD

Series

IARC Scientific Publications

ISBN

9789283221470