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Citation
Tags
HERO ID
758900
Reference Type
Journal Article
Subtype
Review
Title
Non-neoplastic and neoplastic pleural endpoints following fiber exposure
Author(s)
Broaddus, VC; Everitt, JI; Black, B; Kane, AB
Year
2011
Is Peer Reviewed?
1
Journal
Journal of Toxicology and Environmental Health, Part B: Critical Reviews
ISSN:
1093-7404
EISSN:
1521-6950
Volume
14
Issue
1-4
Page Numbers
153-178
Language
English
PMID
21534088
DOI
10.1080/10937404.2011.556049
Web of Science Id
WOS:000290087900006
Abstract
Exposure to asbestos fibers is associated with non-neoplastic pleural diseases including plaques, fibrosis, and benign effusions, as well as with diffuse malignant pleural mesothelioma. Translocation and retention of fibers are fundamental processes in understanding the interactions between the dose and dimensions of fibers retained at this anatomic site and the subsequent pathological reactions. The initial interaction of fibers with target cells in the pleura has been studied in cellular models in vitro and in experimental studies in vivo. The proposed biological mechanisms responsible for non-neoplastic and neoplastic pleural diseases and the physical and chemical properties of asbestos fibers relevant to these mechanisms are critically reviewed. Understanding mechanisms of asbestos fiber toxicity may help us anticipate the problems from future exposures both to asbestos and to novel fibrous materials such as nanotubes. Gaps in our understanding have been outlined as guides for future research.
Keywords
Pharmacy And Pharmacology; Asbestos; Human exposure; Cystic fibrosis; Pathology; Toxicity
Tags
IRIS
•
Asbestos
•
Libby Amphibole Asbestos (Draft, 2011)
OPPT REs
•
OPPT_Asbestos, Part I: Chrysotile_C. Engineering
Total – title/abstract screening
Off topic
•
OPPT_Asbestos, Part I: Chrysotile_D. Exposure
Total – title/abstract screening
Off topic
•
OPPT_Asbestos, Part I: Chrysotile_E. Fate
Total – title/abstract screening
Off topic
•
OPPT_Asbestos, Part I: Chrysotile_F. Human Health
Total – title/abstract screening
On topic
Peer review
Secondary source/ Review
On topic - additional tags for titles/abstracts
Human hazard ID
MOA
•
OPPT_Asbestos, Part I: Chrysotile_Supplemental Search
LitSearch: Sept 2020 (Undated)
ProQuest
PubMed
Toxline
WoS
Legacy Uses
Health Outcomes
•
Nanoscale Carbon
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