US EPA

790404 

Journal Article 

Biochemical studies on phthalic esters--II. Effects of phthalic esters on mitochondrial respiration of rat liver 

Takahashi, T 

1977 

Yes 

Biochemical Pharmacology
ISSN: 0006-2952
EISSN: 1873-2968 

HEEP/77/09509 

26 

1 

19-24 

English 

831723 

Of 10 dialkyl phthalates, dipropyl phthalate [131-16-8] was the most potent inhibitor of mitochondrial state-3 respiration, inhibiting O uptake by 50% and phosphorylation completely; the inhibitory effects were reduced by decreasing or increasing the chain length of this compd. In a series of 9 monoalkyl phthalates, inhibition was increased as the alkyl group was lengthened up to heptyl. Studies with 14 phthalate analogs and related compds. showed that the length of alkyl chains was more important than aromatic ring structure for the inhibitory effects of the phthalates. Dialkyl and monoalkyl phthalates mainly acted as energy-transfer inhibitors and blocked the point before the 2,4-dinitrophenol-sensitive site in the energy-transfer path.