Jump to main content
US EPA
United States Environmental Protection Agency
Search
Search
Main menu
Environmental Topics
Laws & Regulations
About EPA
Health & Environmental Research Online (HERO)
Contact Us
Print
Feedback
Export to File
Search:
This record has one attached file:
Add More Files
Attach File(s):
Display Name for File*:
Save
Citation
Tags
HERO ID
791223
Reference Type
Technical Report
Subtype
NTP
Title
Final report on the developmental toxicity of mono(2-ethylhexyl)phthalate (CAS No. 4376-20-9) in CD-1-Swiss mice. Volume 1. Final study report and appendix
Author(s)
Price, CJ; Marr, MC; Myers, CB; Morrissey, RE; Heindel, JJ
Year
1991
Publisher
National Toxicology Program
Location
Research Triangle Park, NC
Report Number
DART/TER/94000343
Volume
NTIS
Issue
NTIS/PB91-185926
Page Numbers
162 pp
Language
English
URL
https://ntrl.ntis.gov/NTRL/dashboard/searchResults.xhtml?searchQuery=PB91185926
Exit
Abstract
Mono(2-ethylhexyl)phthalate (MEHP) and 2-ethylhexanol (2-EH) are metabolites of di(2-ethylhexyl)phthalate (DEHP), a widely used phthalate ester plasticizer. MEHP (0%, 0.017%, 0.035%, 0.070% or 0.140% in feed) was provided on gestational days (gd) 0 to 17 to timed-pregnant Swiss (CD-1) mice (25-27/group). Average doses were 0, 35, 73, 134 or 269 mg MEHP/kg/day, respectively. At sacrifice (gd 17), the number of resorptions, and dead or live fetuses were recorded. Live or dead fetuses were weighed. Live fetuses were sexed and examined for external, visceral and skeletal malformations. Maternal and developmental effects of MEHP exposure throughout gestation were qualitatively similar to those previously reported for DEHP at approximately equimolar doses administered under comparable experimental conditions (Tyl et al., 1988). The data indicate that MEHP plays a significant role in the expression of DEHP-induced maternal and developmental toxicity.
Keywords
Toxicity; Teratogens; Plasticizers; Graphs(Charts); Reproduction(Biology); Body weight; Dose-response relationships; Mice; Food consumption; Fetal development; Tables(Data); Water consumption; Pathology; Phthalates/mono 2-ethylhexyl; CAS 4376-20-9
NTIS Number
PB91-185926
Tags
•
Phthalates – Targeted Search for Epidemiological Studies
Source – all searches
Toxnet
Excluded
Source – no date limit through June 2013 (Private)
ToxNet
Home
Learn about HERO
Using HERO
Search HERO
Projects in HERO
Risk Assessment
Transparency & Integrity