Health & Environmental Research Online (HERO)


Print Feedback Export to File
791223 
Technical Report 
NTP 
Final report on the developmental toxicity of mono(2-ethylhexyl)phthalate (CAS No. 4376-20-9) in CD-1-Swiss mice. Volume 1. Final study report and appendix 
Price, CJ; Marr, MC; Myers, CB; Morrissey, RE; Heindel, JJ 
1991 
National Toxicology Program 
Research Triangle Park, NC 
DART/TER/94000343 
NTIS 
NTIS/PB91-185926 
162 pp 
English 
Mono(2-ethylhexyl)phthalate (MEHP) and 2-ethylhexanol (2-EH) are metabolites of di(2-ethylhexyl)phthalate (DEHP), a widely used phthalate ester plasticizer. MEHP (0%, 0.017%, 0.035%, 0.070% or 0.140% in feed) was provided on gestational days (gd) 0 to 17 to timed-pregnant Swiss (CD-1) mice (25-27/group). Average doses were 0, 35, 73, 134 or 269 mg MEHP/kg/day, respectively. At sacrifice (gd 17), the number of resorptions, and dead or live fetuses were recorded. Live or dead fetuses were weighed. Live fetuses were sexed and examined for external, visceral and skeletal malformations. Maternal and developmental effects of MEHP exposure throughout gestation were qualitatively similar to those previously reported for DEHP at approximately equimolar doses administered under comparable experimental conditions (Tyl et al., 1988). The data indicate that MEHP plays a significant role in the expression of DEHP-induced maternal and developmental toxicity. 
Toxicity; Teratogens; Plasticizers; Graphs(Charts); Reproduction(Biology); Body weight; Dose-response relationships; Mice; Food consumption; Fetal development; Tables(Data); Water consumption; Pathology; Phthalates/mono 2-ethylhexyl; CAS 4376-20-9 
PB91-185926