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989391 
Journal Article 
Identification of ammonia in gas emanated from human skin and its correlation with that in blood 
Nose, K; Mizuno, T; Yamane, N; Kondo, T; Ohtani, H; Araki, S; Tsuda, T 
2005 
Yes 
Analytical Sciences
ISSN: 0910-6340
EISSN: 1348-2246 
21 
12 
1471-1474 
English 
16379388 
Identifying and measuring the ammonia gas that emanates from human skin, which we called skin gas, has been achieved using a modified gas chromatographic system with a nitrogen-selective detector (flame-thermoionic detector: FTD). The skin gas is collected with a home-made sampling probe or bag, which is used to cover the skin surface of a subject's wrist, or a finger, for 5 min. It was proved that ammonia was present in skin gas for healthy persons and patients with hepatic disease. The average amounts of ammonia were 1.7 +/- 0.4 and 2.7 +/- 0.8 ng/cm2; furthermore, there was a significant difference between them (p < 0.05). In addition, the ammonia levels present in skin gas were correlated with that in blood (r = 0.64, p < 0.05).