Chronic residential exposure to particulate matter air pollution and systemic inflammatory markers | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

1007580

Reference Type

Journal Article

Title

Chronic residential exposure to particulate matter air pollution and systemic inflammatory markers

Author(s)

Hoffmann, B; Moebus, S; Dragano, N; Stang, A; Möhlenkamp, S; Schmermund, A; Memmesheimer, M; Bröcker-Preuss, M; Mann, K; Erbel, R; Jöckel, KH

Year

2009

Is Peer Reviewed?

Yes

Journal

Environmental Health Perspectives
ISSN: 0091-6765
EISSN: 1552-9924

Volume

117

Issue

Page Numbers

1302-1308

Language

English

PMID

19672412

DOI

10.1289/ehp.0800362

Web of Science Id

WOS:000268567100036

Abstract

BACKGROUND: Long-term exposure to urban air pollution may accelerate atherogenesis, but mechanisms are still unclear. The induction of a low-grade systemic inflammatory state is a plausible mechanistic pathway.

OBJECTIVES: We analyzed the association of residential long-term exposure to particulate matter (PM) and high traffic with systemic inflammatory markers.

METHODS: We used baseline data from the German Heinz Nixdorf Recall Study, a population-based, prospective cohort study of 4,814 participants that started in 2000. Fine PM [aerodynamic diameter
RESULTS: In the adjusted analysis, a cross-sectional exposure difference of 3.91 microg/m(3) in PM(2.5) (interdecile range) was associated with increases in hs-CRP of 23.9% [95% confidence interval (CI), 4.1 to 47.4%] and fibrinogen of 3.9% (95% CI, 0.3 to 7.7%) in men, whereas we found no association in women. Chronic traffic exposure was not associated with inflammatory markers. Short-term exposures to air pollutants and temperature did not influence the results markedly.

CONCLUSIONS: Our study indicates that long-term residential exposure to high levels of PM(2.5) is associated with systemic inflammatory markers in men. This might provide a link between air pollution and coronary atherosclerosis.

Keywords

air quality; cardiovascular disease; epidemiology; inflammation; roadway proximity