US EPA

1011836 

Journal Article 

Effects of indoor, outdoor, and personal exposure to particulate air pollution on cardiovascular physiology and systemic mediators in seniors 

Liu, L; Ruddy, T; Dalipaj, M; Poon, R; Szyszkowicz, M; You, HY; Dales, RE; Wheeler, AJ 

2009 

Yes 

Journal of Occupational and Environmental Medicine
ISSN: 1076-2752
EISSN: 1536-5948 

51 

9 

1088-1098 

English 

19701101 

10.1097/JOM.0b013e3181b35144 

WOS:000269896200014 

Objective: To investigate the associations between exposure to particulate air pollution and changes in cardiovascular function and plasma mediators in seniors. Methods: We monitored daily indoor and outdoor black carbon and particulate matter <= 2.5 mu m (PM2.5) and personal. PM2.5 repeatedly for 28 nonsmoking seniors. We then measured their blood pressure, heart rate, and brachial artery Junction, and determined plasma mediators of inflammation, vascular function, and oxidative stress. We tested associations using mixed-effects models. Results: Increases in black carbon and PM2.5 were associated with increases in blood pressure, heart rate, endothelin-1, vascular endothelial growth factor, and oxidative stress marker thiobarbituric acid reactive substances, and a decrease in brachial artery diameter (P < 0.05). Conclusion: Daily exposure to particulate pollution, likely traffic-related, may result in adverse effects on cardiovascular function and blood mediators that modulate vascular system in seniors. (J Occup Environ Med. 2009;51:1088-1098) 

CORONARY-ARTERY-DISEASE;CONCENTRATED AMBIENT PARTICLES;ENDOTHELIAL GROWTH-FACTOR;AFFECT VASCULAR FUNCTION;HEART-RATE-VARIABILITY;OXIDATIVE STRESS;THIOBARBITURIC-ACID;LIPID-PEROXIDATION;HEALTHY-ADULTS;BLOOD-PRESSURE;PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH