Book/Book Chapter
Enterohepatic circulation of the aromatic hydrocarbons benzo[a]pyrene and naphthalene
Hirom, PC; Chipman, JK; Millburn, P; Pue, MA; Rydstrom, J; Montelius, J; Bengtsson, M
Elsvier Science Publishers
Amsterdam, The Netherlands
Extrahepatic drug metabolism and chemical carcinogenesis
Enterohepatic circulation of the aromatic hydrocarbons benzo[a]pyrene and naphthalene. Hirom, P. C.; Chipman, J. K.; Millburn, P.; Pue, M. A. (Med. Sch., St. Mary's Hosp., London W2 1PG, UK). Extrahepatic Drug Metab. Chem. Carcinog., Proc. Int. Meet., 275-81. Edited by: Rydstroem, Jan; Montelius, Johan; Bengtsson, Margot. Elsevier: Amsterdam, Neth. (English) 1983. CODEN: 51CCAK. DOCUMENT TYPE: Conference CA Section: 4 (Toxicology) In both rats and rabbits i.v. administered 14C-labeled benzo[a]pyrene (I) [50-32-8] (3 mmol/kg), the bile was a major excretory route of 14C. However, in the rabbit, the urine contains significantly more of the dose. Enterohepatic circulation of biliary metabolites shows that some 20% of an intraduodenal dose was reexcreted in the bile of both rats and rabbits, but again urinary excretion was significantly higher in the rabbit. In the rabbit, I 9,10-diol [24909-09-9] was the predominant metabolite in bile whereas in the rat I 4,5-diol [28622-84-6] formation and the prodn. 91-20-3 and 17573-21-6 which are cas registry numbers of substances are two of reagents here. of quinones appeared to be the main routes of metab. Bile from both species (contg. ~40 nmol I metabolites/100 mL) showed an increase in reverse gene mutation frequency in the presence of b-glucuronidase without the S9 fraction. In normal rats, 90% of a dose of 14C-labeled naphthalene (II) [91-20-3] was excreted in the urine. The major urinary metabolite was N-acetyl-S-(1,2-dihydro-1-hydroxy-2-naphthyl)cysteine [73092-91-8], a premercapturic acid. However, in bile duct-cannulated rats, 64% of the dose was excreted in the bile (6 h) with the major metabolite being S-(1,2-dihydro-1-hydroxy-2-naphthyl)glutatione [57169-86-5] (70% of biliary 14C in 0-2 h). .
9/27/04; Enterohepatic Circulation; Hydrocarbons; ORISE; metabolism;
Rydstrom, J; Montelius, J; Bengtsson, M
International Meeting on Extrahepatic Drug Metabolism and Chemical Carcinogenesis
Stockholm, Sweden
May 17-20, 1983