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1015695 
Journal Article 
Ameliorative effect Trichosanthes dioica root against experimentally induced arsenic toxicity in male albino rats 
Bhattacharya, S; Haldar, PK 
In Press 
Yes 
Environmental Toxicology and Pharmacology
ISSN: 1382-6689
EISSN: 1872-7077 
33 
394-402 
English 
The present study evaluated the ameliorative potential of hydroalcoholic extract of Trichosanthes dioica root (TDA) against arsenic induced toxicity in male albino rats. TDA (5 and 10mg/kg) was administered orally to rats for 20 consecutive days before oral administration of sodium arsenite (10mg/kg) for 8 days. Then the body weights, organ weights, haematological profiles, serum biochemical profile; hepatic and renal antioxidative parameters viz. lipid peroxidation, reduced and oxidized glutathione, glutathione-S-transferase, glutathione peroxidase, glutathione reductase, superoxide dismutase, catalase and DNA fragmentation were evaluated. Pretreatment with TDA markedly and significantly normalized body weights, organ weights, haematological profiles, serum biochemical profile and significantly modulated all the hepatic and renal biochemical parameters and reduced DNA fragmentation in arsenic intoxicated rats. The present findings conclude that T. dioica root possessed remarkable ameliorative effect against arsenic induced organ toxicity in male albino rats mediated by alleviation of arsenic induced oxidative stress by multiple mechanisms. 
Arsenic toxicity; Trichosanthes dioica; Root; Oxidative stress; Sodium arsenite 
• Arsenic Hazard ID
     1. Initial Lit Search
          PubMed
          WOS
          ToxNet
          WOS
          Considered New
     2. Lit Search Updates through Oct 2015
          WOS
          Considered
     4. Considered through Oct 2015
     6. Cluster Filter through Oct 2015
     7. Other Studies through Oct 2015
          Episodic exposure/acute exposure
          MOA
          iAs MOA Literature Categorization
               Cytotoxicity and Regenerative Proliferation
               Epigenetic Mechanisms
• Arsenic (Inorganic)
     1. Literature
          PubMed
          Toxline, TSCATS, & DART
          Web of Science
          Lit search updates through Oct 2015
     3. Hazard ID Screening
          Other potentially supporting studies
     4. Adverse Outcome Pathways/Networks Screening
          Relevant
     5. Susceptibility Screening
          Excluded/Not relevant
• Arsenic MOA
     4. Adverse Outcome Pathways
          Oxidative stress related effects (includes non-specific SH reactions)
     5. Health Effect
          Liver Effects
          Renal Effects
     1. MOA Literature Screening
          Health Effect Screening
          MOA Cluster
          Susceptibility Screening
• Arsenic Susceptibility
     5. Health Effect
          Not Relevant
     1. Susceptibility Literature Screening
          Keyword Search
     2. Excluded
          MOA/Mechanistic
     3. References Identified During Review