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Citation
Tags
HERO ID
1016267
Reference Type
Journal Article
Title
Cannabis arteritis
Author(s)
Combemale, P; Consort, T; Denis-Thelis, L; Estival, JL; Dupin, M; Kanitakis, J
Year
2005
Is Peer Reviewed?
Yes
Journal
British Journal of Dermatology
ISSN:
0007-0963
EISSN:
1365-2133
Volume
152
Issue
1
Page Numbers
166-169
Language
English
PMID
15656820
DOI
10.1111/j.1365-2133.2005.06340.x
Web of Science Id
WOS:000227012800026
Abstract
The main causes of arteriopathy in young patients include drugs, metabolic diseases, pseudoxanthoma elasticum and Buerger's disease. Arteritis due to Cannabis indica was first reported in 1960, and the role of this drug as a risk factor for arteritis was confirmed in several subsequent publications. A 38-year-old smoker with no previous contributory medical history except for long-standing cannabis abuse developed a dry necrotic lesion of the left big toe. Imaging examinations revealed proximal arteriopathy of the lower limbs that predominated on the left side. He had no atherogenic or thrombogenic risk factors, and no signs of pseudoxanthoma elasticum were found. Remarkably, the development of arteritis paralleled cannabis abuse. The course was slowly favourable after weaning from the drug, vasodilator treatment and hyperbaric oxygen therapy. Despite some subtle clinical differences (more proximal than distal involvement), cannabis arteritis may be considered as a particular form of Buerger's disease, where cannabis, along with tobacco, seems to cause arterial lesions. Along with the noxious effects of cannabis on vessels, a role for contaminating arsenic is also possible. Cannabis arteritis is not widely known, but may prove not to be so rare if one considers consumption of cannabis besides that of tobacco.
Keywords
Buerger's disease; cannabis; drug abuse; juvenile; arteritis
Tags
IRIS
•
Arsenic (Inorganic)
1. Literature
PubMed
Toxline, TSCATS, & DART
Web of Science
4. Adverse Outcome Pathways/Networks Screening
Excluded/Not relevant
Title/Abstract screening
•
Arsenic MOA
1. MOA Literature Screening
MOA Cluster
3. Excluded
Other not relevant
Dragon Screened
•
Inorganic Arsenic (7440-38-2) [Final 2025]
1. Initial Lit Search
PubMed
WOS
ToxNet
4. Considered through Oct 2015
6. Cluster Filter through Oct 2015
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