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1018804 
Journal Article 
The ars operon of Escherichia coli confers arsenical and antimonial resistance 
Carlin, A; Shi, W; Dey, S; Rosen, BP 
1995 
Yes 
Journal of Bacteriology
ISSN: 0021-9193
EISSN: 1098-5530 
BIOSIS/95/10559 
177 
4 
981-986 
English 
7860609 
WOS:A1995QG25000016 
The chromosomally encoded arsenical resistance (ars) operon subcloned into a multicopy plasmid was found to confer a moderate level of resistance to arsenite and antimonite in Escherichia coli. When the operon was deleted from the chromosome, the cells exhibited hypersensitivity to arsenite, antimonite, and arsenate. Expression of the ars genes was inducible by arsenite. By Southern hybridization, the operon was found in all strains of E. coli examined but not in Salmonella typhimurium, Pseudomonas aeruginosa, or Bacillus subtilis. 
Biochemical Studies-Nucleic Acids; Biochemical Studies-Minerals; Replication; Metabolism-Minerals; Toxicology-General; Toxicology-Antidotes and Preventative Toxicology (1972- ); Physiology and Biochemistry of Bacteria; Genetics of Bacteria and Viruses; Pseudomonadaceae (1992- ); Enterobacteriaceae (1992- ); Endospore-forming Gram-Positives (1992- ) 
IRIS
• Arsenic (Inorganic)
     1. Literature
          PubMed
          Toxline, TSCATS, & DART
          Web of Science
     4. Adverse Outcome Pathways/Networks Screening
          Excluded/Not relevant
               Title/Abstract screening
• Arsenic MOA
     1. MOA Literature Screening
          MOA Cluster
     3. Excluded
          Other not relevant
               Dragon Screened
• Inorganic Arsenic (7440-38-2) [Final 2025]
     1. Initial Lit Search
          PubMed
          WOS
          ToxNet
     4. Considered through Oct 2015
     6. Cluster Filter through Oct 2015