US EPA

1051520 

Journal Article 

Active components from Siberian ginseng (Eleutherococcus senticosus) for protection of amyloid β(25-35)-induced neuritic atrophy in cultured rat cortical neurons 

Bai, Y; Tohda, C; Zhu, S; Hattori, M; Komatsu, K 

2011 

Yes 

Journal of Natural Medicines
ISSN: 1340-3443
EISSN: 1861-0293 

65 

3-4 

417-423 

English 

21301979 

10.1007/s11418-011-0509-y 

WOS:000291746900002 

Not only neuronal death but also neuritic atrophy and synaptic loss underlie the pathogenesis of Alzheimer's disease as direct causes of the memory deficit. Extracts of Siberian ginseng (the rhizome of Eleutherococcus senticosus) were shown to have protective effects on the regeneration of neurites and the reconstruction of synapses in rat cultured cortical neurons damaged by amyloid β (Aβ)(25-35), and eleutheroside B was one of the active constituents. In this study, a comprehensive evaluation of constituents was conducted to explore active components from Siberian ginseng which can protect against neuritic atrophy induced by Aβ(25-35) in cultured rat cortical neurons. The ethyl acetate, n-butanol and water fractions from the methanol extract of Siberian ginseng showed protective effects against Aβ-induced neuritic atrophy. Twelve compounds were isolated from the active fractions and identified. Among them, eleutheroside B, eleutheroside E and isofraxidin showed obvious protective effects against Aβ(25-35)-induced atrophies of axons and dendrites at 1 and 10 μM. 

Siberian ginseng; Eleutherococcus senticosus; Amyloid beta; Neuritic atrophy; Eleutheroside B; Eleutheroside E