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Citation
Tags
HERO ID
11705
Reference Type
Journal Article
Title
Quantitative comparison of maternal ethanol and maternal tertiary butanal diet on postnatal development
Author(s)
Daniel, MA; Evans, MA
Year
1982
Is Peer Reviewed?
Yes
Journal
Journal of Pharmacology and Experimental Therapeutics
ISSN:
0022-3565
EISSN:
1521-0103
Volume
222
Issue
2
Page Numbers
294-300
Language
English
PMID
7097549
Web of Science Id
WOS:A1982PC14900002
URL
https://www.scopus.com/inward/record.uri?eid=2-s2.0-0019997909&partnerID=40&md5=d7f60110033a64ae20ef7e1809caa308
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Abstract
The mechanism by which developmental anomalies associated with the fetal alcohol syndrome are produced is not understood. Current hypotheses include altered maternal function and direct action of ethanol or its metabolic product, acetaldehyde, on embryonic tissue. Pregnant mice were fed liquid diets containing either ethanol (3.6%, w/v) or tertiary butanol in concentrations of 0.50, 0.75 and 1.00% (w/v) from day 6 to day 20 of gestation. Untreated surrogate maternal animals were substituted in half of the original litters to gain insight into the role played by maternal nutritional and behavioral factors. Quantitatively, t-butanol was approximately 5 times more potent than ethanol in producing a developmental delay in post-parturition physiological and psychomotor performance scores. The existence at significant postnatal maternal nutritional and behavioral factors affecting lactation and/or nesting behavior were also evident at the higher concentrations of alcohol. The results from this study are consistent with the hypothesis that ethanol per se and not acetaldehyde is primarily responsible for the fetal alcohol syndrome.
Tags
•
tert-Butanol
Considered Studies
Electronic Search
Sources of Health Effects Data
Animal studies
Cited in Document
Cited in Public Comment Draft – May 2016
Toxicological Review
•
ETBE
Additional Search Strategies
DePeyster et al
Combined Dataset (After duplicates removed electronically)
Excluded / Not on Topic
Other chemical/non ETBE studies
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