Garnier, R; Poupon, J; Villa, A
Occupations that involve exposure to arsenic include the production of arsenic compounds, non-ferrous metal smelting, the production and use of arsenic-based dyes, the production of micro devices, certain glass manufacturing operations, leather tanning and CCA (chromium, copper and arsenic-based) wood treatment. Often fatal, acute poisoning results in gastroenteritis, hydroelectrolytic and haemodynamic disturbances, renal tubular damage, hepatic cytolysis, cardiomyopathy, encephalopathy (confusion, coma, convulsions) and metabolic acidosis. Long-term exposure to arsenic can cause dermatological, neurological, cardiovascular, metabolic and carcinogenic effects. Several recent epidemiological studies indicate increased risks of abortion, premature birth and in-utero deaths associated with arsenic exposure during pregnancy. The standard biological indicator of arsenic exposure is the sum of the urinary concentrations of inorganic arsenic and of its main metabolites.
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