US EPA

1171655 

Journal Article 

Abstract 

Biliary excretion of arsenic 

Klaassen, CD 

1973 

1 

Toxicology and Applied Pharmacology
ISSN: 0041-008X
EISSN: 1096-0333 

25 

3 

475 

English 

WOS:A1973Q218800108 

http://www.sciencedirect.com/science/article/pii/0041008X73903190
Exit
 

is part of a larger document 3114922 Abstracts of papers for the Twelfth Annual Meeting of the Society of Toxicology, New York, New York March 18–22, 1973

The disappearance of arsenic-74 from the blood and plasma of rats and its excretion into the bile was measured for 2 hr after the iv administration of 0. 01, 0. 46, 1. 0, 2. 1, and 4. 6 mg/kg of arsenic given as the trichloride. Arsenic disappearance from the plasma was biphasic; the half-life during the late phase was greater than 2 hr. Even though the arsenic was injected iv, the concentration in the blood increased throughout the first 2 hr. Arsenic was repidly excreted into the bile, reaching its highest rate of excretion 6 min after administration; the rate then rapidly decreased. This rapid decrease in excretion is due to redistribution of arsenic from the liver to the blood. Arsenic enters bile against a bile/plasma concentration gradient of 630, 8 min after a 1 mg/kg dose of arsenic. At this time the liver/plasma gradient is 17 and the liver/bile gradient is 37. Twenty-five percent of the arsenic administered to bile duct-cannulated rats is excreted into the bile within 2 hr after administration. However, less than 10% of the administered dose is excreted into the feces of intact rats over a 7-day period. These data demonstrate that arsenic is excreted into the bile of rats. Further, these data suggest that arsenic is transported into bile by an active transport system, and then enters an enterohepatic circulation. (Author abstract by permission) (Abstract No. 96) 

Twelfth Annual Meeting of the Society of Toxicology 

New York, New York 

March 18–22, 1973