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Citation
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HERO ID
1248967
Reference Type
Journal Article
Title
Toxicokinetics/toxicodynamics links bioavailability for assessing arsenic uptake and toxicity in three aquaculture species
Author(s)
Chen, W-Y; Liao, C-M
Year
2012
Is Peer Reviewed?
Yes
Journal
Environmental Science and Pollution Research
ISSN:
0944-1344
EISSN:
1614-7499
Volume
19
Issue
9
Page Numbers
3868-3878
Language
English
PMID
22684900
DOI
10.1007/s11356-012-1012-z
Web of Science Id
WOS:000309476600023
URL
http://link.springer.com/10.1007/s11356-012-1012-z
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Abstract
The purpose of this study was to link toxicokinetics/toxicodynamics (TK/TD) and bioavailability-based metal uptake kinetics to assess arsenic (As) uptake and bioaccumulation in three common farmed species of tilapia (Oreochromis mossambicus), milkfish (Chanos chanos), and freshwater clam (Corbicula fluminea). We developed a mechanistic framework by linking damage assessment model (DAM) and bioavailability-based Michaelis-Menten model for describing TK/TD and As uptake mechanisms. The proposed model was verified with published acute toxicity data. The estimated TK/TD parameters were used to simulate the relationship between bioavailable As uptake and susceptibility probability. The As toxicity was also evaluated based on a constructed elimination-recovery scheme. Absorption rate constants were estimated to be 0.025, 0.016, and 0.175 mL g-1 h-1 and As uptake rate constant estimates were 22.875, 63.125, and 788.318 ng g-1 h-1 for tilapia, milkfish, and freshwater clam, respectively. Here we showed that a potential trade-off between capacities of As elimination and damage recovery was found among three farmed species. Moreover, the susceptibility probability can also be estimated by the elimination-recovery relations. This study suggested that bioavailability-based uptake kinetics and TK/TD-based DAM could be integrated for assessing metal uptake and toxicity in aquatic organisms. This study is useful to quantitatively assess the complex environmental behavior of metal uptake and implicate to risk assessment of metals in aquaculture systems.
Keywords
Arsenic; Bioavailability; Uptake; Ecotoxicology; Susceptibility; Fish; Shellfish
Tags
IRIS
•
Arsenic Hazard ID
1. Initial Lit Search
PubMed
WOS
ToxNet
WOS
Considered New
2. Lit Search Updates through Oct 2015
WOS
Considered
4. Considered through Oct 2015
6. Cluster Filter through Oct 2015
7. Other Studies through Oct 2015
PBPK/TK
•
Arsenic (Inorganic)
1. Literature
PubMed
Toxline, TSCATS, & DART
Web of Science
Lit search updates through Oct 2015
3. Hazard ID Screening
Other potentially supporting studies
5. Susceptibility Screening
Excluded/Not relevant
•
Arsenic Susceptibility
1. Susceptibility Literature Screening
Keyword Search
2. Excluded
Not Relevant
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