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HERO ID
1294538
Reference Type
Journal Article
Subtype
Review
Title
Endocrine disruptors: from endocrine to metabolic disruption
Author(s)
Casals-Casas, C; Desvergne, B
Year
2011
Is Peer Reviewed?
Yes
Journal
Annual Review of Physiology
ISSN:
0066-4278
EISSN:
1545-1585
Volume
73
Page Numbers
135-162
Language
English
PMID
21054169
DOI
10.1146/annurev-physiol-012110-142200
Web of Science Id
WOS:000288968800007
Abstract
Synthetic chemicals currently used in a variety of industrial and agricultural applications are leading to widespread contamination of the environment. Even though the intended uses of pesticides, plasticizers, antimicrobials, and flame retardants are beneficial, effects on human health are a global concern. These so-called endocrine-disrupting chemicals (EDCs) can disrupt hormonal balance and result in developmental and reproductive abnormalities. New in vitro, in vivo, and epidemiological studies link human EDC exposure with obesity, metabolic syndrome, and type 2 diabetes. Here we review the main chemical compounds that may contribute to metabolic disruption. We then present their demonstrated or suggested mechanisms of action with respect to nuclear receptor signaling. Finally, we discuss the difficulties of fairly assessing the risks linked to EDC exposure, including developmental exposure, problems of high- and low-dose exposure, and the complexity of current chemical environments.
Keywords
persistent organic pollutants; phthalates; bisphenol A; obesity; diabetes; nuclear receptors
Tags
IRIS
•
Phthalates – Targeted Search for Epidemiological Studies
Source – all searches
WOS
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Source – no date limit through June 2013 (Private)
WOS
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