US EPA

1315800 

Journal Article 

Evaluation of hydroxypropyl methylcellulose phthalate 50 as film forming polymer from aqueous dispersion systems 

Muhammad, NA; Boisvert, W; Harris, MR; Weiss, J 

1992 

Yes 

Drug Development and Industrial Pharmacy
ISSN: 0363-9045
EISSN: 1520-5762 

Informa Healthcare 

NEW YORK 

IPA/93/1021185 

Ind 

REF 10 

1787-1797 

English 

10.3109/03639049209040902 

WOS:A1992JM91100005 

IPA COPYRIGHT: ASHP The elasticity of hydroxypropyl methylcellulose phthalate (HPMCP 50) films prepared from aqueous dispersion systems and the influence of plasticizer type and level on the elasticity were studied; the release properties of a water soluble drug from pellets coated with HPMCP 50 with 30% plasticizer containing various levels of hydroxypropyl cellulose (HPC) or hydroxypropyl methylcellulose (HPMC) were also investigated. HPMCP 50 alone without a plasticizer did not form a film. As the concentration of the plasticizer triethyl citrate was increased, the elasticity of HPMCP 50 films was increased. Similar results were obtained with the plasticizer diethyl phthalate. For pellets, a high coating level was required to achieve adequate protection in 0.06 N hydrochloric acid (HCl). Drug release from coated pellets was found to be dependent upon the type and the level of the water soluble polymer incorporated with HPMCP 50. Drug release was increased as the percentage of HPC was increased. Higher release rates were obtained with HPMC compared to HPC. Coating level significantly influenced drug release in 0.06 N HCl; however, less of an effect was observed at pH 5.5. 

Hydroxypropyl methylcellulose phthalate; films; effects; Hydroxypropyl methylcellulose; coated pellets; Hydroxypropyl cellulose; Triethyl citrate; effects; elasticity; Diethyl phthalate; Plasticizers; effects; Elasticity; films; Concentration; effects; effects; Coatings; drug release; Pellets; release; drugs effects; drugs; hydroxypropyl methylcellulose phthalate coated pellets; Hydrogen ion concentration