US EPA

1315803 

Journal Article 

Evaluation of aqueous dispersions of Eudragit L 100-55 for their enteric coating properties 

Plaizier-Vercammen, J; Van Molle, M 

1991 

1 

STP Pharma Sciences
ISSN: 1157-1489 

IPA/92/1003193 

T 

REF 22 

267-271 

IPA COPYRIGHT: ASHP Capsule formulations containing aspirin and sodium salicylate were coated with an aqueous dispersion of poly(ethyl acrylate-methacryl acid) (Eudragit L-100-55), diethyl phthalate, dibutyl phthalate, and triacetin as plasticizers and talc as filler and studied to determine the viscosity of the aqueous dispersions, disintegration times, effects of pH, drug diffusion, and water permeation as a function of the amount of coating. The amount of coating needed to ensure enteric coating properties was small and was influenced by plasticizer type and concentration and by the active compounds. Disintegration started from pH 5 or 5.4, depending on the plasticizer used. Stability was excellent for capsules containing aspirin, but not for those containing sodium salicylate. 

Aspirin; capsules; enteric coatings; Sodium salicylate; Eudragit L-100-55; coatings; enteric; Diethyl phthalate; effects; aspirin; Dibutyl phthalate; Triacetin; Talc; Water; permeation; enteric coated capsules; Analgesics and antipyretics; aspirin(Analgesics and antipyretics; sodium salicylate(Analgesics and antipyretics; enteric; Polymers; Plasticizers; Excipients; Concentration; Viscosity; enteric coatings; Dispersions; Disintegration; Hydrogen ion concentration; disintegration; Diffusion; Stability; Poly(ethyl acrylate-methacryl acid)