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1454181 
Journal Article 
A new method for the synthesis of chiral beta-branched alpha-amino acids 
Spangenberg, T; Schoenfelder, A; Breit, B; Mann, A 
2007 
1 
Organic Letters
ISSN: 1523-7060
EISSN: 1523-7052 
9 
20 
3881-3884 
English 
17803310 
A new method for the synthesis of chiral beta-branched alpha-amino acids based on a copper-mediated directed allylic substitution reaction with Grignard reagents is reported. This is the first case in which a delta-stereogenic center is controlling the diastereoselectivity of an o-DPPB-directed allylic substitution. Depending on the alkene geometry of the starting material either diastereomer, anti or syn, is accessible with good levels of acyclic stereocontrol. 
IRIS
• n-Butanol
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