Antidiabetic activity of phenolic compounds from Pecan bark in streptozotocin-induced diabetic rats
Abdallah, HM; Salama, MM; Abd-Elrahman, EH; El-Maraghy, SA
| HERO ID | 1459848 |
|---|---|
| In Press | No |
| Year | 2011 |
| Title | Antidiabetic activity of phenolic compounds from Pecan bark in streptozotocin-induced diabetic rats |
| Authors | Abdallah, HM; Salama, MM; Abd-Elrahman, EH; El-Maraghy, SA |
| Journal | Phytochemistry Letters |
| Volume | 4 |
| Issue | 3 |
| Page Numbers | 337-341 |
| Abstract | The n-butanol fraction (BF) of bark of Pecan tree, Carya illinoinensis (Wangenh) K. Koch (Juglandaceae) afforded two new flavonol methyl ether: caryatin-3' sulfate (6) and caryatin-3' methyl ether-7-O-beta-D-glucoside (7) while five known phenolics (1-5) were isolated from its ethyl acetate fraction (EAF). The structures of isolated compounds were established based on 1D and 2D NMR spectroscopy. The isolated compounds were investigated for their hypoglycaemic, antioxidant as well as the aldose reductase (AR) inhibitory effect in lenses of streptozocin diabetic rats. All the isolated compounds showed significant hypoglycaemic and antioxidant activities, except 5 and 6. A marked AR-inhibitory effect was identified for compounds 2, 3 and 7. (C) 2011 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved. |
| Doi | 10.1016/j.phytol.2011.07.004 |
| Wosid | WOS:000296534500029 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Source: Web of Science WOS:000296534500029 |
| Is Public | Yes |
| Language Text | English |
| Keyword | Pecan bark; Aldose reductase; Methoxy flavonoids; Sulphated flavonoids; Antidiabetic |