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1463443 
Journal Article 
Development of a Practical One-Pot Synthesis of Indigo from Indole 
Yamamoto, Y; Inoue, Y; Takaki, U; Suzuki, H 
2011 
Yes 
Bulletin of the Chemical Society of Japan
ISSN: 0009-2673
EISSN: 1348-0634 
84 
1 
82-89 
WOS:000287835500010 
A novel and highly practical one-pot synthesis of indigo from indole via 3-position selective oxidation and dimerization of the indole framework was developed. Using 0.1 mol % of molybdenum complex and 2.2 equivalents of cumene hydroperoxide in tert-butyl alcohol, the reaction was complete in 7 h and pure indigo was obtained in 81% yield as a deep-blue solid just by filtration. The described one-step method renders the pure indigo readily available on a large scale using only inexpensive raw materials. 
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