US EPA

1470687 

Journal Article 

Abstract 

Uptake kinetics of jet fuel aromatic hydrocarbons from aqueous solutions studied by a membrane-coated fiber technique 

Riviere, JE; Xia, X 

2004 

1 

Toxicologist
ISSN: 0731-9193 

TOX/4001557 

78 

S-1 

265 

English 

The absorption of aromatic hydrocarbons from aqueous media is a critical step involved in their transport and deposition in a human body after jet fuel exposure. We have developed a membrane-coated fiber (MCF) technique to study this process, in which a polymer membrane is coated on an inert fiber as a permeation membrane. A polydimethylsiloxane (PDMS) membrane intending to simulate human stratum corneum and a polyacylate (PA) membrane intending to simulate cell membrane were used in this study. The uptake kinetics of the major aromatic components in jet fuel were studied in a flow system, which provided a constant concentration for the prolonged permeation experiments. The absorption profiles of the aromatic compounds were regressed with a mathematical model of the MCF technique. The equilibrium absorption amount and a kinetic parameter that determined the absorption kinetics were obtained from the regression for each compound. The uptake and elimination rate constants of 6 benzene derivatives and 3 naphthalene derivatives were determined with PDMS and PA MCFs. An equilibration method and a regression method were developed to determine membrane/water partition coefficients. The PDMS/water partition coefficients of the benzene and naphthalene derivatives were linearly correlated with their octanol/ water partition coefficients (LogKpdms/w=0.871LogKo/w-0.241, R2=0.995). The PA/water partition coefficients of the benzene derivatives and the naphthalene derivatives were correlated differently with their octanol/water partition coefficients. The correlation equations for benzene and naphthalene derivatives were LogKpa/w=0.865LogKo/w+0.0045, R2=0.997 and LogKpa/w=0.763LogKo/w+0.911, R2=1.00, respectively. This shows that the MCF technique can detect the subtle differences in intermolecular interactions of the two group derivatives between the two-membrane/water systems. 

43rd Annual Meeting of the Society of Toxicology 

Baltimore, MD 

March 21-25, 2004