US EPA

1487275 

Technical Report 

Structure-activity comparison of hydrazine to other nasotoxic chemicals 

Godin, CS; Wall, HG 

1992 

ADA2625887 

GRA and I 

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The biotransformation of 19 chemicals that have caused nasal epithelial toxicity in-long-term carcinogenesis experiments in laboratory rodents was compared with the biotransformation of hydrazine, in order to determine if these chemicals share common metabolic pathways. Ten of the 19 chemicals were tumorigenic; four were epoxides or epoxide-formers; three were metabolized to reactive aldehydes; and one was metabolized to a lactone ring. The two remaining chemicals, p-cresidene and 2,6-xylidene, possess an amino group that can undergo biotransformation to reactive metabolites in a way similar to hydrazine, but there is no evidence to support this hypothesis. Therefore, none of the 19 chemicals are metabolized in a way similar to hydrazine.... Structure-activity, Hydrazine, Nasotoxicity, Carcinogenicity. 

Hydrazines; *Toxicity; *Nose(Anatomy); Aldehydes; Carcinogenesis; Chemicals; Laboratories; Lactones; Rings; Rodents; Biology; Transformations; Epithelium; Metabolism; Epoxidation; Metabolites; Molecular structure; Halogen compounds; Methacrylates; Naphthalenes; Structure-activity relationships; Epoxides; Cresol; Amino groups; Biotransformation