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172951 
Journal Article 
Protection of adrenal and male gonadal functions by androgen in lead-treated rats 
Biswas, NM; Ghosh, PK 
2006 
Yes 
Kathmandu University Medical Journal
ISSN: 1812-2027
EISSN: 1812-2078 
4 
2 
218-221 
English 
18603901 
MEDLINE:18603901 
The potential health hazard of the large amounts of Lead that occurs in canned baby food, domestic water from lead-lined tanks and, in printing and petroleum industries.

Lead acetate administration at a does of 8 mg/kg body weight for 21 days resulted a significant increase in adrenal steroidogenic enzyme (Delta5-3beta- HSD) and serum levels of corticosterone, while serum levels of testosterone, FSH, LH and testicular spermatogenesis were decreased in albino rats. But lead-treated rats received exogenous testosterone for the last 14 days of lead treatment, showed prevention of adrenocortical hyperactivity by decreasing adrenal Delta5-3beta-HSD activity and serum level of corticosterone. Testosterone administration also increased serum level of testosterone, FSH and LH along with spermatogenesis.

The results suggest that testosterone supplementation in lead-treated rats protects adrenocortical activity and testicular spermatogenesis.