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Citation
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HERO ID
191147
Reference Type
Journal Article
Title
DNA methylation in development and human disease
Author(s)
Gopalakrishnan, S; Van Emburgh, BO; Robertson, KD
Year
2008
Is Peer Reviewed?
1
Journal
Mutation Research
ISSN:
0027-5107
EISSN:
1873-135X
Volume
647
Issue
1-2
Page Numbers
30-38
DOI
10.1016/j.mrfmmm.2008.08.006
Web of Science Id
WOS:000261703600005
Abstract
DNA methylation is a heritable and stable epigenetic mark associated with transcriptional repression. Changes in the patterns and levels of global and regional DNA methylation regulate development and contribute directly to disease states such as cancer. Recent findings provide intriguing insights into the epigenetic crosstalk between DNA methylation, histone modifications, and small interfering RNAs in the control of cell development and carcinogenesis. In this review, we summarize the recent studies in DNA methylation primarily focusing on the interplay between different epigenetic modifications and their potential role in gene silencing in development and disease. Although the molecular mechanisms involved in the epigenetic crosstalk are not fully understood, unraveling their precise regulation is important not only for understanding the underpinnings of cellular development and cancer, but also for the design of clinically relevant and efficient therapeutics using stem cells and anticancer drugs that target tumor initiating cells.
Keywords
DNA methyltransferase; Polycomb; Cancer; ICF syndrome; Histone modifications; Gene regulation; Chromatin
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ISA-PM (2009 Final Project Page)
2009 Final
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ISA-PM (2019)
Peer Input Draft
Chapter 5
1st Draft
Chapter 10
Final ISA
Chapter 10
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