The epigenomics of cancer | Health & Environmental Research Online (HERO)

Health & Environmental Research Online (HERO)

Print Feedback Export to File

This record has one attached file:

Citation
Tags

HERO ID

191153

Reference Type

Journal Article

Title

The epigenomics of cancer

Author(s)

Jones, PA; Baylin, SB

Year

2007

Is Peer Reviewed?

Yes

Journal

Cell
ISSN: 0092-8674
EISSN: 1097-4172

Volume

128

Issue

Page Numbers

683-92

Abstract

Aberrant gene function and altered patterns of gene expression are key features of cancer. Growing evidence shows that acquired epigenetic abnormalities participate with genetic alterations to cause this dysregulation. Here, we review recent advances in understanding how epigenetic alterations participate in the earliest stages of neoplasia, including stem/precursor cell contributions, and discuss the growing implications of these advances for strategies to control cancer.