US EPA

2155948 

Journal Article 

Abstract 

Computer-assisted reduction and display of gas-chromatographic data from long-term toxicity studies of commercial mixtures of polychlorinated biphenyls in chickens and in rats 

Bush, B; Lo, FC; Baker, FD 

1974 

1 

Toxicology and Applied Pharmacology
ISSN: 0041-008X
EISSN: 1096-0333 

29 

1 

105 

English 

WOS:A1974T653800082 

is part of a larger document 3378179 Abstracts of papers for the Thirteenth Annual Meeting of the Society of Toxicology, Washington, D.C. March 10–14, 1974

Homologs and isomers of PCB represented by 18 gas chlomatographic zones have been traced through the tissues of adult animals to their young in long-term studies of the chicken and the rat. Three or more tissue types from each animal sacrificed have been analyzed and in order to facilitate the chemical analysis and to reduce the mass of data produced, several novel techniques have been developed and will be described. The Hewlett-Packard 7600A system was employed. In the chicken experiment, integrator output was converted into logarithmic bar charts to give a visual display of relative changes in concentration during residence in the animals, using a Wang Programming Calculator and Data Plotter. Conclusions were drawn from the data, in spite of the large disparities observed between individuals, by determining frequencies of occurrence above and below datum lines drawn across the bar charts. In the rat experiment, Fortran programs were written to display the data as linear or logarithmic bar charts, tabulate nominal concentrations of each chromatographic zone, plot the variation of each zone concentration with time for each tissue type in the adult, fetus and pup throughout the experiment. Detailed observations and conclusions will be described in an accompanying presentation. 

Thirteenth Annual Meeting of the Society of Toxicology 

Washington, D.C. 

March 10–14, 1974