Super-hydrophilic zwitterionic poly(carboxybetaine) and amphiphilic non-ionic poly(ethylene glycol) for stealth nanoparticles | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

2156306

Reference Type

Journal Article

Title

Super-hydrophilic zwitterionic poly(carboxybetaine) and amphiphilic non-ionic poly(ethylene glycol) for stealth nanoparticles

Author(s)

Cao, Z; Jiang, S

Year

2012

Is Peer Reviewed?

Journal

Nano Today
ISSN: 1748-0132

Volume

Issue

Page Numbers

404-413

DOI

10.1016/j.nantod.2012.08.001

Web of Science Id

WOS:000310863200007

Abstract

This review compares two types of non-fouling polymers, the widely used nonionic poly(ethylene glycol) (PEG) and the recently established zwitterionic poly(carboxybetaine) (PCB), for their use in creating stealth nanoparticles (NPs) for drug delivery and protein protection. While both types of polymers exhibit reasonable non-fouling properties, such as good protein and colloidal stability and extended blood circulation time in vivo, amphiphilic PEG has negative effects on proteins and NPs due to its hydrophobic nature, including reduced protein bioactivity, instability of assembled NPs, and lipid bilayer destabilization. These problems can be overcome by super-hydrophilic PCB. (c) 2012 Elsevier Ltd. All rights reserved.

Keywords

Polyethylene glycol; Zwitterions; Non-fouling; Protein conjugation; Liposome; Drug delivery