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Citation
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HERO ID
2174751
Reference Type
Journal Article
Title
Analytical performance of a triple quadrupole mass spectrometer compared to a high resolution mass spectrometer for the analysis of polybrominated diphenyl ethers in fish
Author(s)
Mackintosh, SA; Perez-Fuentetaja, A; Zimmerman, LR; Pacepavicius, G; Clapsadl, M; Alaee, M; Aga, DS
Year
2012
Is Peer Reviewed?
Yes
Journal
Analytica Chimica Acta
ISSN:
0003-2670
EISSN:
1873-4324
Volume
747
Page Numbers
67-75
Language
English
PMID
22986137
DOI
10.1016/j.aca.2012.08.021
Web of Science Id
WOS:000309568600009
URL
http:///www.elsevier.com
Exit
Abstract
Polybrominated diphenyl ethers (PBDEs) are a class of flame retardants used globally in many consumer products and industrial applications. Traditionally, gas chromatography-high resolution mass spectrometry (GC-HR-MS) is the method of choice for analysis of PBDEs in environmental samples because it offers high sensitivity and selectivity, resulting in less interferences. However, the specificity offered by gas chromatography-triple quadrupole tandem mass spectrometry (GC-QQQ-MS/MS), operated in selected reaction monitoring mode, provides a more affordable alternative to GC-HR-MS for the analysis of PBDEs in complex environmental samples. In this study, an analytical method was developed for the analysis of 41 PBDE congeners in fish using GC-QQQ-MS/MS. Results from the analysis of three fish species [lake trout (Salvelinus namaycush), yellow perch (Perca flavescens), and round goby (Neogobius melanostomus)) using GC-QQQ-MS/MS were compared with those obtained by GC-HR-MS. These species were selected because they represent varying levels of lipid-rich matrix and contaminant loads. Instrumental limits of detection for the GC-QQQ-MS/MS ranged from 0.04 pg to 41 pg, whereas those for the GC-HR-MS ranged from 5 pg to 85 pg. The PBDE values obtained from these two methods were highly correlated, R-2 values >0.7, for all three fish species, supporting the suitability of GC-QQQ-MS/MS for analysis of PBDEs in fish with varying fat content. (C) 2012 Elsevier B.V. All rights reserved.
Keywords
Polybrominated diphenyl ethers; Triple quadrupole mass spectrometry; High-resolution mass spectrometry; Fish; Brominated flame retardants; Methods
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PCBs
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