Analytical performance of a triple quadrupole mass spectrometer compared to a high resolution mass spectrometer for the analysis of polybrominated diphenyl ethers in fish | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

2174751

Reference Type

Journal Article

Title

Analytical performance of a triple quadrupole mass spectrometer compared to a high resolution mass spectrometer for the analysis of polybrominated diphenyl ethers in fish

Author(s)

Mackintosh, SA; Perez-Fuentetaja, A; Zimmerman, LR; Pacepavicius, G; Clapsadl, M; Alaee, M; Aga, DS

Year

2012

Is Peer Reviewed?

Yes

Journal

Analytica Chimica Acta
ISSN: 0003-2670
EISSN: 1873-4324

Volume

747

Page Numbers

67-75

Language

English

PMID

22986137

DOI

10.1016/j.aca.2012.08.021

Web of Science Id

WOS:000309568600009

URL

http:///www.elsevier.com
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Abstract

Polybrominated diphenyl ethers (PBDEs) are a class of flame retardants used globally in many consumer products and industrial applications. Traditionally, gas chromatography-high resolution mass spectrometry (GC-HR-MS) is the method of choice for analysis of PBDEs in environmental samples because it offers high sensitivity and selectivity, resulting in less interferences. However, the specificity offered by gas chromatography-triple quadrupole tandem mass spectrometry (GC-QQQ-MS/MS), operated in selected reaction monitoring mode, provides a more affordable alternative to GC-HR-MS for the analysis of PBDEs in complex environmental samples. In this study, an analytical method was developed for the analysis of 41 PBDE congeners in fish using GC-QQQ-MS/MS. Results from the analysis of three fish species [lake trout (Salvelinus namaycush), yellow perch (Perca flavescens), and round goby (Neogobius melanostomus)) using GC-QQQ-MS/MS were compared with those obtained by GC-HR-MS. These species were selected because they represent varying levels of lipid-rich matrix and contaminant loads. Instrumental limits of detection for the GC-QQQ-MS/MS ranged from 0.04 pg to 41 pg, whereas those for the GC-HR-MS ranged from 5 pg to 85 pg. The PBDE values obtained from these two methods were highly correlated, R-2 values >0.7, for all three fish species, supporting the suitability of GC-QQQ-MS/MS for analysis of PBDEs in fish with varying fat content. (C) 2012 Elsevier B.V. All rights reserved.

Keywords

Polybrominated diphenyl ethers; Triple quadrupole mass spectrometry; High-resolution mass spectrometry; Fish; Brominated flame retardants; Methods