US EPA

2215400 

Journal Article 

Review 

Lipophilic chemical exposure as a cause of cardiovascular disease 

Zeliger, HI 

2013 

Yes 

Interdisciplinary Toxicology
ISSN: 1337-6853 

6 

2 

55-62 

English 

24179429 

10.2478/intox-2013-0010 

https://search.proquest.com/docview/1439233501?accountid=171501
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Environmental chemical exposure has been linked to numerous diseases in humans. These diseases include cancers; neurological and neurodegenerative diseases; metabolic disorders including type 2 diabetes, metabolic syndrome and obesity; reproductive and developmental disorders; and endocrine disorders. Many studies have associated the link between exposures to environmental chemicals and cardiovascular disease (CVD). These chemicals include persistent organic pollutants (POPs); the plastic exudates bisphenol A and phthalates; low molecular weight hydrocarbons (LMWHCs); and poly nuclear aromatic hydrocarbons (PAHs). Here it is reported that though the chemicals reported on differ widely in chemical properties and known points of attack in humans, a common link exists between them. All are lipophilic species that are found in serum. Environmentally induced CVD is related to total lipophilic chemical load in the blood. Lipophiles serve to promote the absorption of otherwise not absorbed toxic hydrophilic species that promote CVD. 

Pollution Abstracts; Toxicology Abstracts; Health & Safety Science Abstracts; Hydrocarbons; Aromatic hydrocarbons; Lipophilic; Absorption; Plasticity; Chemical properties; Pollutants; Persistent organic pollutants; Obesity; Phthalic acid; Neurodegenerative diseases; Diabetes mellitus; Endocrine diseases; Phthalates; Bisphenol A; Exudates; Cardiovascular diseases; Metabolic disorders; X 24350:Industrial Chemicals; H 6000:Natural Disasters/Civil Defense/Emergency Management; P 6000:TOXICOLOGY AND HEALTH