US EPA

2347062 

Journal Article 

Oral exposure of Kunming mice to diisononyl phthalate induces hepatic and renal tissue injury through the accumulation of ROS: Protective effect of melatonin 

Ma, P; Yan, B; Zeng, Q; Liu, X; Wu, Y; Jiao, M; Liu, C; Wu, J; Yang, X 

2014 

Yes 

Food and Chemical Toxicology
ISSN: 0278-6915
EISSN: 1873-6351 

68 

247-256 

English 

24685826 

10.1016/j.fct.2014.03.027 

WOS:000337653000027 

has other version or edition 7978853 Di-iso-nonyl phthalate oral exposure of Kunming mice induces hepatic and renal tissue injury

Diisononyl phthalate (DINP) has been widely used in polyvinyl chloride (PVC) products and is ubiquitous as a substitute; however, its toxicity due to exposure remains to be determined. This study investigated the oxidative damage induced by DINP and the induced production of the pro-inflammation cytokines interleukin-1 (IL-1) and tumour necrosis factor-α (TNF-α). Oral exposure to DINP induced oxidative damage and inflammatory responses in liver and kidney tissues through the accumulation of ROS, which may be an underlying mechanism for its toxicity. These changes may contribute to hepatic and renal histopathological alterations. Our data suggest that oxidative stress is involved in DINP-induced toxicity and that the co-administration of melatonin exerts a protective effect against DINP-induced toxicity. 

diisononyl phthalate; melatonin; oxidative stress; reactive oxygen species; Interleukin-1; tumour necrosis factor alpha