US EPA

2934828 

Journal Article 

Fabrication and Surface Properties of Hydrolyticly Function-switchable Polymer Brush 

Shi Suqing; Zhao Yang; Zhang Qin; Gao Na; Yang Yang; Gong Yongkuan 

2014 

1 

Gaodeng Xuexiao Huaxue Xuebao / Chemical Journal of Chinese Universities
ISSN: 0251-0790 

35 

5 

1093-1099 

10.7503/cjcu20131092 

WOS:000336477200031 

A hydrolysable cationic polycarboxybetaine ester polymer brush(PCBMA-1C2) was fabricated by photografting method with surface-coupled tertiary amine as hetergenous hydrogen donor and benzophenone (BP) as photosensitizer. The hydrolysis of PCBMA-1C2 modified surface was evaluated by studying the hydrolysis behavior of CBMA-1C2 monomer under different ammonium hydroxide concentrations. X-ray photoelectron spectroscopy(XPS) and water contact angle were used to monitor the chemical changes and hydrophilicity, respectively. The protein adsorption and platelet adhesion experiments were used to evaluate the interaction between the material surface and the biomolecules. The results show that when the concentrations of ammonium hydroxide are 0. 1, 0. 2, 0. 3 and 0. 4 mol/L, the degrees of hydrolysis(DH) of terminal ester of CBMA-1C2 monomer are 6%, 43%, 56% and almost 100%, respectively. Compared with Glass-PCBMA-1C2 surface, with the increase of DH, the protein adsorption of BSA are reduced by 3%, 76%, 93% and 96%, and that of Fg are reduced by 11%, 45%, 90% and 96%, respectively. When DH >50%, the hydrolyzed Glass-PCB MA-1C2 surface exhibits good resistance of protein adsorption and platelet adhesion. 

Carboxybetaine ester; Hydrolysis; Function switch; Polymer brush; Surface property