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Citation
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HERO ID
3121500
Reference Type
Journal Article
Title
Acute increase in blood pressure during inhalation of coarse particulate matter air pollution from an urban location
Author(s)
Byrd, JB; Morishita, M; Bard, RL; Das, R; Wang, L; Sun, Z; Spino, C; Harkema, J; Dvonch, JT; Rajagopalan, S; Brook, RD
Year
2016
Is Peer Reviewed?
1
Journal
Journal of the American Society of Hypertension
ISSN:
1933-1711
EISSN:
1878-7436
Volume
10
Issue
2
Page Numbers
133-139.e4
Language
English
PMID
26750378
DOI
10.1016/j.jash.2015.11.015
Web of Science Id
WOS:000370889000007
Abstract
Particulate matter (PM) air pollution is a leading global risk factor for cardiovascular mortality. Although exposure to fine PM <2.5 μm raises arterial blood pressure (BP), few studies have evaluated the impact of coarse PM which differs in size (2.5-10 μm), sources, and chemistry. Twenty-nine healthy adults (30.4 ± 8.2 years) underwent a randomized double-blind crossover study involving 2-hour exposures to concentrated ambient coarse PM (164.2 ± 80.4 μg/m(3)) at an urban location (Dearborn, Michigan) versus filtered air. Cardiovascular outcomes were measured during, immediately, and 2 hours after exposures. Both systolic (1.9 mm Hg; 95% confidence interval: 0.96, 2.8; P < .001) and diastolic (1.9 mm Hg; 95% confidence interval: 1.1, 2.7; P < .001) BP levels were higher throughout coarse PM compared with filtered air exposures by mixed-model analyses. Heart rate variability, endothelial function, and arterial compliance were not significantly affected. Brief exposure to coarse PM in an urban environment raises arterial BP. These findings add mechanistic support to the contention that coarse PM may be capable of promoting cardiovascular events.
Keywords
Endothelial function; environment; heart rate variability; hypertension
Tags
NAAQS
•
ISA-PM (2019)
Peer Input Draft
Chapter 7
Considered
1st Draft
Chapter 6
In Scope
Mode of action
ST PM Cardiovascular
LT PM Cardiovascular
ST PM Metabolic
LT PM Metabolic
ST PM Respiratory
LT PM Respiratory
ST PM Nervous
LT PM Nervous
PM Repro-Dev
PM Cancer-Genotox
Final ISA
Chapter 6
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