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Journal Article 
Acute increase in blood pressure during inhalation of coarse particulate matter air pollution from an urban location 
Byrd, JB; Morishita, M; Bard, RL; Das, R; Wang, L; Sun, Z; Spino, C; Harkema, J; Dvonch, JT; Rajagopalan, S; Brook, RD 
Journal of the American Society of Hypertension
ISSN: 1933-1711
EISSN: 1878-7436 
Particulate matter (PM) air pollution is a leading global risk factor for cardiovascular mortality. Although exposure to fine PM <2.5 μm raises arterial blood pressure (BP), few studies have evaluated the impact of coarse PM which differs in size (2.5-10 μm), sources, and chemistry. Twenty-nine healthy adults (30.4 ± 8.2 years) underwent a randomized double-blind crossover study involving 2-hour exposures to concentrated ambient coarse PM (164.2 ± 80.4 μg/m(3)) at an urban location (Dearborn, Michigan) versus filtered air. Cardiovascular outcomes were measured during, immediately, and 2 hours after exposures. Both systolic (1.9 mm Hg; 95% confidence interval: 0.96, 2.8; P < .001) and diastolic (1.9 mm Hg; 95% confidence interval: 1.1, 2.7; P < .001) BP levels were higher throughout coarse PM compared with filtered air exposures by mixed-model analyses. Heart rate variability, endothelial function, and arterial compliance were not significantly affected. Brief exposure to coarse PM in an urban environment raises arterial BP. These findings add mechanistic support to the contention that coarse PM may be capable of promoting cardiovascular events. 
Endothelial function; environment; heart rate variability; hypertension 
• ISA-PM (current)
     Peer Input Draft
          Chapter 7
     1st Draft
          Chapter 6
     In Scope
          Mode of action
          ST PM Cardiovascular
          LT PM Cardiovascular
          ST PM Metabolic
          LT PM Metabolic
          ST PM Respiratory
          LT PM Respiratory
          ST PM Nervous
          LT PM Nervous
          PM Repro-Dev
          PM Cancer-Genotox
     Final ISA
          Chapter 6