US EPA

3859100 

Journal Article 

Reproducibility discrepancies following reanalysis of raw data for a previously published study on diisononyl phthalate (DINP) in rats 

Chen, M; Alyea, R; Morfeld, P; Otter, R; Kemmerling, J; Palermo, C 

2017 

Data in Brief
ISSN: 2352-3409 

13 

208-213 

English 

28616453 

10.1016/j.dib.2017.05.043 

BCI:BCI201900149147 

https://linkinghub.elsevier.com/retrieve/pii/S2352340917302342
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A 2011 publication by Boberg et al. entitled "Reproductive and behavioral effects of diisononyl phthalate (DINP) in perinatally exposed rats" [1] reported statistically significant changes in sperm parameters, testicular histopathology, anogenital distance and retained nipples in developing males. Using the statistical methods as reported by Boberg et al. (2011) [1], we reanalyzed the publically available raw data ([dataset] US EPA (United States Environmental Protection Agency), 2016) [2]. The output of our reanalysis and the discordances with the data as published in Boberg et al. (2011) [1] are highlighted herein. Further discussion of the basis for the replication discordances and the insufficiency of the Boberg et al. (2011) [1] response to address them can be found in a companion letter of correspondence (doi: 10.1016/j.reprotox.2017.03.013.; (Morfeld et al., 2011) [3]). 

Reproducibility; Reproductive toxicology; Statistical reanalysis; Diisononyl phthalate (DINP)