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HERO ID
3926304
Reference Type
Journal Article
Title
Association between exposure to organochlorine compounds and maternal thyroid status: Role of the iodothyronine deiodinase 1 gene
Author(s)
Llop, S; Murcia, M; Alvarez-Pedrerol, M; Grimalt, JO; Santa-Marina, L; Julvez, J; Goñi-Irigoyen, F; Espada, M; Ballester, F; Rebagliato, M; Lopez-Espinosa, MJ
Year
2017
Is Peer Reviewed?
1
Journal
Environment International
ISSN:
0160-4120
EISSN:
1873-6750
Volume
104
Page Numbers
83-90
Language
English
PMID
28395858
DOI
10.1016/j.envint.2016.12.013
Web of Science Id
WOS:000402007000010
Abstract
INTRODUCTION:
Exposure to organochlorine compounds (OCs) may interfere with thyroid hormone (TH) homeostasis. The disruption of the deiodinase (DIO) enzymes has been proposed as a mechanism of action.
AIM:
To evaluate the association between exposure to OCs and TH status in pregnant women, as well as to explore the role of genetic variations in the DIO1 and DIO2 genes.
METHODS:
The study population (n=1128) was composed of pregnant women who participated in the INMA Project (Spain, 2003-2006). Hexachlorobenzene (HCB), 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene (4,4´-DDE), b-hexachlorocyclohexane (b-HCH), polychlorobiphenyl (PCB) congeners 138, 153 and 180, thyroid stimulating hormone (TSH), total triiodothyronine (TT3) and free thyroxine (FT4) were measured in serum samples taken during the first trimester of pregnancy (mean [standard deviation (SD)]: 13.5 [2] weeks of gestation). Polymorphisms in DIO1 (rs2235544) and DIO2 (rs12885300) were genotyped in maternal DNA. Sociodemographic and dietary characteristics were obtained by questionnaire.
RESULTS:
A 2-fold increase in HCB was associated with lower TT3 (% change=-1.48; 95%CI: -2.36, -0.60). Women in the third tertile for b-HCH had lower TT3 (% change=-3.19; 95%CI: -5.64, -0.67). The interactions between DIO1 rs2235544 and PCB153 and b-HCH were statistically significant. The inverse association between PCB153 and TT3 was the strongest among women with AA genotype. Women with CC genotype presented the strongest inverse association between b-HCH and FT4.
CONCLUSION:
Exposure to HCB and b-HCH was associated to a disruption in maternal TT3. The DIO1 rs2235544 SNP modified the association between exposure to some of the OCs (specifically b-HCH and PCB153) and maternal thyroid hormone levels. These results strengthen the hypothesis that DIO enzymes play a role in explaining the disruption of thyroid hormones in relation to exposure to OCs.
Tags
IRIS
•
PCBs
Hazard ID: Epidemiological evidence
Mechanistic
Litsearches
LitSearch: August 2016-August 2017
PubMed
WoS
•
PCBs Epi Hazard ID
Health Effects
Endocrine
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