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4138885 
Book/Book Chapter 
Arsenic, cadmium and lead 
Flora, SJS; Pachauri, V; Saxena, G 
2011 
Academic Press 
San Diego, CA 
Reproductive and developmental toxicology 
415-438 
English 
WOS:000318575300034 
has other version or edition 4785808 Arsenic, cadmium, and lead
This chapter discusses the toxic effects of conventionally known metals such as lead, arsenic and mercury on the reproductive system and developmental processes. The chapter comprises a mechanistic understanding of these toxicities with respect to the toxicokinetics of the metal and related risk assessment. Metal toxicity has been documented as one of the prime mass toxicants especially in the case of occupational and environmental hazards. Metals may cause a wide spectrum of reproductive and developmental adverse effects such as reduced fertility, abortions, retarded growth at the intrauterine cavity, skeletal deformities, malformations and retarded development especially of the nervous system. Any teratogen is known to produce toxic manifestations in small doses either directly or injury mediated via systemic toxicity mostly by virtue of high-dose effect. The important mechanisms of action of arsenic are placental transfer, oxidative stress, direct binding with thiol group etc. The toxicity of arsenic in male and female reproductive organs is also explained. It also throws some light on the therapeutic strategies for metal toxicity. The chapter concludes that the advent of awareness towards environmental, occupational and lifestyle exposure to metals and reports revealing their toxic potential and mechanism is mainly responsible for increasing investigations into their reproductive and developmental effects. 
Gupta, RC 
9780123820327