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HERO ID
4239887
Reference Type
Journal Article
Title
Near-infrared induced phase-shifted ICG/Fe3O4loaded PLGA nanoparticles for photothermal tumor ablation
Author(s)
Niu, C; Xu, Y; An, S; Zhang, M; Hu, Y; Wang, L; Peng, Q
Year
2017
Is Peer Reviewed?
1
Journal
Scientific Reports
EISSN:
2045-2322
Volume
7
Issue
1
Page Numbers
5490
Language
English
PMID
28710483
DOI
10.1038/s41598-017-06122-1
Web of Science Id
WOS:000405464200127
URL
https://www.proquest.com/scholarly-journals/near-infrared-induced-phase-shifted-icg-fe3o4/docview/1920194663/se-2
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Abstract
Near-infrared (NIR) laser-induced photothermal therapy (PTT) uses a photothermal agent to convert optical energy into thermal energy and has great potential as an effective local, minimally invasive treatment modality for killing cancer cells. To improve the efficacy of PTT, we developed poly(lactide-co-glycolide) (PLGA) nanoparticles (NPs) encapsulating superparamagnetic iron oxide (Fe3O4), indocyanine green (ICG), and perfluoropentane (PFP) as synergistic agents for NIR laser-induced PTT. We fabricated a novel type of phase-shifting fluorescent magnetic NPs, Fe3O4/ICG@PLGA/PFP NPs, that effectively produce heat in response to NIR laser irradiation for an enhanced thermal ablation effect and a phase-shift thermoelastic expansion effect, and thus, can be used as a photothermal agent. After in vitro treatment of MCF-7 breast cancer cells with Fe3O4/ICG@PLGA/PFP NPs and NIR laser irradiation, histology and electron microscopy confirmed severe damage to the cells and the formation of many microbubbles with iron particles at the edge or outside of the microbubbles. In vivo experiments in mice with MCF-7 tumors demonstrated that Fe3O4/ICG@PLGA/PFP NPs could achieve tumor ablation upon NIR laser irradiation with minimal toxicity to non-irradiated tissues. Together, our results indicate that Fe3O4/ICG@PLGA/PFP NPs can be used as effective nanotheranostic agents for tumor ablation.
Keywords
Animals; Cell Death; Ferric Compounds/chemistry; Fluorocarbons/chemistry; Hyperthermia, Induced; Indocyanine Green/chemistry; Infrared Rays; MCF-7 Cells; Mammary Neoplasms, Animal/pathology/therapy; Mice, Nude; Nanoparticles/chemistry/ultrastructure; Phototherapy; Polylactic Acid-Polyglycolic Acid Copolymer/chemistry
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