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HERO ID
4728406
Reference Type
Journal Article
Title
Anogenital distance as a phenotypic signature through infancy
Author(s)
Priskorn, L; Petersen, JH; Jørgensen, N; Kyhl, HB; Andersen, MS; Main, KM; Andersson, AM; Skakkebaek, NE; Jensen, TK
Year
2018
Is Peer Reviewed?
1
Journal
Pediatric Research
ISSN:
0031-3998
EISSN:
1530-0447
Volume
83
Issue
3
Page Numbers
573-579
Language
English
PMID
29155806
DOI
10.1038/pr.2017.287
Web of Science Id
WOS:000430304300005
Abstract
BackgroundAnogenital distance (AGD) has been suggested to represent a phenotypic signature reflecting in utero androgen action. However, it is not known whether an individual's AGD at birth correlates to the AGD later in life. We investigate correlations of AGD between 3 and 18 months of age and assess reproducibility of measurements.MethodsWe measured AGD from anus to scrotum (AGDas) and to penis (AGDap) in 407 boys, and to posterior fourchette (AGDaf) and clitoris (AGDac) in 282 girls. Each measure was repeated three times at 3 and 18 months of age, and some children were, furthermore, examined by two different examiners. We assessed age-related changes and reproducibility of measurements.ResultsAGD increased between the two examinations and correlated within the child. A large proportion of the observed variation in AGD was due to true differences between the children (AGDas: 62%, AGDap: 40%, AGDaf: 30%, AGDac: 21%), and measurement error due to between- and within-examiner variation was low.ConclusionsOur study showed that measures of AGD within a child correlated during infancy, especially in boys and particularly for AGD measured as the distance between anus and scrotum. A planned cohort follow-up through childhood and puberty will reveal whether AGD represents a phenotypic signature throughout life.
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Phthalates – Targeted Search for Epidemiological Studies
Source - August 2018 Update
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