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HERO ID
53500
Reference Type
Journal Article
Title
Erythrocyte lead-binding protein after occupational exposure: I Relationship to lead toxicity
Author(s)
Raghavan, SRV; Culver, BD; Gonick, HC
Year
1980
Is Peer Reviewed?
Yes
Journal
Environmental Research
ISSN:
0013-9351
EISSN:
1096-0953
Volume
22
Issue
1
Page Numbers
264-270
DOI
10.1016/0013-9351(80)90138-3
Abstract
Lead content was determined in various fractions of red blood cell (RBC) hemolysates from normal controls and from three groups of lead-exposed workers: without toxicity, toxicity associated with high blood lead levels, and toxicity associated with low blood lead levels. The most significant finding was a decrease in the lead bound to a 10,000 molecular weight protein in the group of workers with toxicity at low blood lead levels (43 to 54 μg%). These results suggest that workers who have diminished capacity for synthesizing this low-molecular-weight lead-binding protein are at increased risk for developing lead toxicity at relatively low blood lead levels.
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NAAQS
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ISA-Lead (2013 Final Project Page)
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