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5933459 
Journal Article 
Urinary biomarkers of phthalates exposure and risks of thyroid cancer and benign nodule 
Liu, C; Deng, YL; Zheng, TZ; Yang, P; Jiang, XQ; Liu, EN; Miao, XP; Wang, LQ; Jiang, M; Zeng, Q 
2020 
Yes 
Journal of Hazardous Materials
ISSN: 0304-3894
EISSN: 1873-3336 
383 
121189 
English 
31541958 
WOS:000502887900063 
Phthalates have been reported to affect the function and growth of thyroid. However, there is little data on the effect of phthalates on thyroid oncogenesis. Here we explored the associations between phthalates exposure and the risks of thyroid cancer and benign nodule. We sex-matched 144 thyroid cancer, 138 benign nodule patients and 144 healthy adults from Wuhan, China. Eight phthalate metabolites in spot urine samples were quantified using high-performance liquid chromatography and tandem mass spectrometry. The associations of creatinine-corrected urinary phthalate metabolites with the risks of thyroid cancer and benign nodule were assessed using multivariable logistic regression models. We found that urinary monomethyl phthalate (MMP), mono(2-ethyl-5hydroxyhexyl) phthalate (MEHHP) and mono(2-ethylhexyl) phthalate (MEHP) associated with increased risks of thyroid cancer and nodule, with adjusted odds ratios (ORs) ranging from 1.74 to 4.78 comparing the extreme tertiles, and urinary monobutyl phthalate (MBP) was associated with decreased risks of thyroid cancer and benign nodule (all P for trends < 0.05). Male-specific positive associations of urinary monoethyl phthalate (MEP) with thyroid cancer and nodule as well as urinary mono(2-ethyl-5-oxohexyl) phthalate (MEOHP) with thyroid cancer were also observed. Our results suggest that exposure to certain phthalates may contribute to increased risks of thyroid cancer and benign nodule. 
article; case-control study; exposure; thyroid cancer; thyroid benign nodule; biomarkers; carcinogenesis; environmental exposure; health effects assessments; high performance liquid chromatography; metabolites; odds ratio; patients; phthalates; regression analysis; risk reduction; tandem mass spectrometry; thyroid neoplasms 
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