EVALUATION OF ENTERIC COATED CAPSULES COATED WITH AMMONIATED WATER SOLUTIONS OF CELLULOSE-ACETATE PHTHALATE AND CELLULOSE-ACETATE TRIMELLITATE | Health & Environmental Research Online (HERO)

Health & Environmental Research Online (HERO)

Print Feedback Export to File

This record has one attached file:

Citation
Tags

HERO ID

5933780

Reference Type

Journal Article

Title

EVALUATION OF ENTERIC COATED CAPSULES COATED WITH AMMONIATED WATER SOLUTIONS OF CELLULOSE-ACETATE PHTHALATE AND CELLULOSE-ACETATE TRIMELLITATE

Author(s)

Plaiziervercammen, JA; Steppe, K

Year

1992

Volume

Issue

Page Numbers

1050-1052

Web of Science Id

WOS:A1992KE68000004

Abstract

Enteric coated capsules, coated with ammoniated water solutions of cellulose acetate phthalate (CAP) and cellulose acetate trimellitate (CAT), using Triacetin, Myvacet 9-40 and Diethylphthalate as plasticizers were evaluated for their enteric coating properties. The resistance in artificial gastric fluid (0.1 mol/l HCl) increased as a function of the amount coating. 3 h artificial gastric resistance was observed with about 5 mg/cm2 coating. Disintegration at pH 6.5 was fast. Great differences with the coated capsules were observed when testing them at lower pH values. CAT capsules being more sensitive than CAP capsules. The uptake of solvent is important. The diffusion of active product is small. The capsules were stable after 6 months of storage.

Keywords

CELLULOSE ACETATE PHTHALATE; AMMONIATED WATER SOLUTIONS; ENTERIC COATING PROPERTIES; CELLULOSE ACETATE TRIMELLITATE; AMMONIATED WATER SOLUTIONS; ENTERIC COATING PROPERTIES