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5933780 
Journal Article 
EVALUATION OF ENTERIC COATED CAPSULES COATED WITH AMMONIATED WATER SOLUTIONS OF CELLULOSE-ACETATE PHTHALATE AND CELLULOSE-ACETATE TRIMELLITATE 
Plaiziervercammen, JA; Steppe, K 
1992 
54 
12 
1050-1052 
Enteric coated capsules, coated with ammoniated water solutions of cellulose acetate phthalate (CAP) and cellulose acetate trimellitate (CAT), using Triacetin, Myvacet 9-40 and Diethylphthalate as plasticizers were evaluated for their enteric coating properties. The resistance in artificial gastric fluid (0.1 mol/l HCl) increased as a function of the amount coating. 3 h artificial gastric resistance was observed with about 5 mg/cm2 coating. Disintegration at pH 6.5 was fast. Great differences with the coated capsules were observed when testing them at lower pH values. CAT capsules being more sensitive than CAP capsules. The uptake of solvent is important. The diffusion of active product is small. The capsules were stable after 6 months of storage. 
CELLULOSE ACETATE PHTHALATE; AMMONIATED WATER SOLUTIONS; ENTERIC COATING PROPERTIES; CELLULOSE ACETATE TRIMELLITATE; AMMONIATED WATER SOLUTIONS; ENTERIC COATING PROPERTIES 
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• Diethyl phthalate (DEP)
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