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HERO ID
5933780
Reference Type
Journal Article
Title
EVALUATION OF ENTERIC COATED CAPSULES COATED WITH AMMONIATED WATER SOLUTIONS OF CELLULOSE-ACETATE PHTHALATE AND CELLULOSE-ACETATE TRIMELLITATE
Author(s)
Plaiziervercammen, JA; Steppe, K
Year
1992
Volume
54
Issue
12
Page Numbers
1050-1052
Web of Science Id
WOS:A1992KE68000004
Abstract
Enteric coated capsules, coated with ammoniated water solutions of cellulose acetate phthalate (CAP) and cellulose acetate trimellitate (CAT), using Triacetin, Myvacet 9-40 and Diethylphthalate as plasticizers were evaluated for their enteric coating properties. The resistance in artificial gastric fluid (0.1 mol/l HCl) increased as a function of the amount coating. 3 h artificial gastric resistance was observed with about 5 mg/cm2 coating. Disintegration at pH 6.5 was fast. Great differences with the coated capsules were observed when testing them at lower pH values. CAT capsules being more sensitive than CAP capsules. The uptake of solvent is important. The diffusion of active product is small. The capsules were stable after 6 months of storage.
Keywords
CELLULOSE ACETATE PHTHALATE; AMMONIATED WATER SOLUTIONS; ENTERIC COATING PROPERTIES; CELLULOSE ACETATE TRIMELLITATE; AMMONIATED WATER SOLUTIONS; ENTERIC COATING PROPERTIES
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IRIS
•
Diethyl phthalate (DEP)
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