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629430 
Journal Article 
Predicting modes of toxic action from chemical structure: Acute toxicity in the fathead minnow (Pimephales promelas) 
Russom, CL; Bradbury, SP; Broderius, SJ; Hammermeister, DE; Drummond, RA 
1997 
Yes 
Environmental Toxicology and Chemistry
ISSN: 0730-7268
EISSN: 1552-8618 
BIOSIS/97/17741 
16 
5 
948-967 
English 
WOS:A1997WX06500014 
BIOSIS COPYRIGHT: BIOL ABS. In the field of aquatic toxicology, quantitative structure-activity relationships (QSARs) have developed as scientifically credible models for predicting the toxicity of chemicals when little or no empirical data are available. In recent years, there has been an evolution of QSAR development and application from that of a chemical-class perspective to one that is more consistent with assumptions regarding modes of toxic action. The objective of this research was to develop procedures that relate modes of acute toxic action in the fathead minnow (Pimephales promelas) to chemical structures and properties. An empirically derived database for diverse chemical structures of acute toxicity and corresponding modes of toxic action was developed through joint toxic action studies, the establishment of toxicodynamic profiles, and behavioral and dose-response interpretation of 96-h LC50 tests. Using the results from these efforts, as well as principles in the toxicological litera 
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