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Tags
HERO ID
6315679
Reference Type
Journal Article
Title
Chronic PFAS-exposure under environmentally relevant conditions delays development in northern leopard frog (Rana pipiens) larvae
Author(s)
Flynn, RW; Iacchetta, M; de Perre, C; Lee, L; SepĂșlveda, MS; Hoverman, JT
Year
2020
Is Peer Reviewed?
Yes
Journal
Environmental Toxicology and Chemistry
ISSN:
0730-7268
EISSN:
1552-8618
Volume
40
Issue
3
Page Numbers
711-716
Language
English
PMID
32072676
DOI
10.1002/etc.4690
Web of Science Id
WOS:000522067000001
Abstract
Perfluoroalkyl substances (PFAS) are pervasive in aquatic systems globally and capable of causing detrimental effects on human and wildlife health. However, most studies are conducted under artificial conditions that are not representative of environmental exposures. Environmental exposures are characterized by multiple routes of exposure, low aquatic PFAS levels, and greater environmental variability than laboratory tests. Determining whether these factors influence toxicity is critical for understanding the effects of PFAS on aquatic life, including amphibians. Our goal was to assess the impact of PFAS on an amphibian under semi-realistic conditions. We reared northern leopard frog (Rana pipiens) larvae in outdoor mesocosms containing sediment spiked to low, medium, and high levels (nominally 10, 100, or 1000 ppb dw) of perfluorooctanesulfonic acid (PFOS) or perfluorooctanoic acid (PFOA) for 30 days. Larvae in all PFOS treatments and the medium-PFOA treatment were ~1.5 Gosner stages less developed than control animals after 30 days. Notably, these developmental delays were observed at PFOS concentrations in the water as low as 0.06 ppb, which is considerably lower than levels associated with developmental effects in laboratory studies. Our results suggest that deriving toxicity values from laboratory studies examining aquatic exposure only may underestimate the effects of environmental PFAS exposure. This article is protected by copyright. All rights reserved.
Keywords
article; Lithobates pipiens; amphibians; aquatic organisms; chemistry; ecotoxicology; perfluorooctane sulfonic acid; perfluorooctanoic acid; sediments; toxicity; wildlife
Tags
PFAS
•
Additional PFAS (formerly XAgency)
•
PFAS 150
Missing 2021 searches
•
PFOA (335-67-1) and PFOS (1763-23-1)
LitSearch: Feb 2019 - May 2020
PubMed
WoS
Literature Search Update (Apr 2019 - Sep 2020)
PubMed
WOS
LitSearch Update (Sept 2020 - Feb 2022)
PubMed
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