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Citation
Tags
HERO ID
6323927
Reference Type
Journal Article
Title
Green tea polyphenols and epigallocatechin-3-gallate protect against perfluorodecanoic acid induced liver damage and inflammation in mice by inhibiting NLRP3 inflammasome activation
Author(s)
Wang, D; Gao, Q; Wang, T; Kan, Z; Li, X; Hu, L; Peng, CY; Qian, F; Wang, Y; Granato, D
Year
2020
Is Peer Reviewed?
Yes
Journal
Food Research International
ISSN:
0963-9969
EISSN:
1873-7145
Publisher
ELSEVIER
Location
AMSTERDAM
Volume
127
Page Numbers
108628
Language
English
PMID
31882076
DOI
10.1016/j.foodres.2019.108628
Web of Science Id
WOS:000509620100039
Abstract
Perfluorodecanoic acid (PFDA) is a highly toxic food contaminant that is extensively used in food applications as surface antifouling agent. In this present study, we aimed to assess whether green tea polyphenols (GTPs) and epigallocatechin-3-gallate (EGCG) exert protective effects against PFDA-induced liver damage and inflammation in mice. A mouse model to evaluate liver toxicity was established by giving mice drinking water containing different concentrations of PFDA. GTPs or EGCG (0.32%, w/v) were co-administered to mice exposed to PFDA in drinking water. Overall, GTPs and EGCG extended the survival time and inhibited weight loss among mice who received a lower dose of PFDA. Moreover, GTPs and EGCG ameliorated hepatic oxidative stress, cell apoptosis, necrosis, steatosis, edema, and degeneration, reduced hepatic inflammation and NLRP3 inflammasome activation caused by a moderate dose of PFDA. Taken together, these results show that GTPs or EGCG (or green tea intake) supplements can be beneficial for people exposed to PFDA.
Keywords
Green tea polyphenols; Functional foods; Tea catechins; EGCG; In vivo study; NLRP3 inflammasome; Perfluorodecanoic acid; Oxidative stress
Tags
PFAS
•
Additional PFAS (formerly XAgency)
•
PFAS 150
Missing 2021 searches
•
PFDA
Literature Search Update 5/2020
PubMed
Literature Search Update 4/2021
PubMed
WoS
Scopus: April 2021
June 2022 Pelch Database
Literature Searches (through April 2023 update and post-public comment/peer review)
Other
Published PFAS SEMs
Title & Abstract Screening
Tagged as Supplemental
Full Text Screening
Studies Meeting PECO
Animal health effects studies
•
PFOA (335-67-1) and PFOS (1763-23-1)
LitSearch: Feb 2019 - May 2020
WoS
Literature Search Update (Apr 2019 - Sep 2020)
WOS
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