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Citation
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HERO ID
633056
Reference Type
Journal Article
Title
Modification of lipoperoxidative effects of dichloroacetate and trichloroacetate is associated with peroxisome proliferation
Author(s)
Austin, EW; Okita, JR; Okita, RT; Larson, JL; Bull, RJ
Year
1995
Is Peer Reviewed?
1
Journal
Toxicology
ISSN:
0300-483X
EISSN:
1879-3185
Report Number
BIOSIS/95/17436
Book Title
Toxicology
Volume
97
Issue
1-3
Page Numbers
59-69
Language
English
PMID
7716793
DOI
10.1016/0300-483X(94)02926-L
Web of Science Id
WOS:A1995QT01200008
Abstract
Pretreatment of male B6C3F1 mice with clofibric acid (CFA) or trichloroacetic acid (TCA) in the drinking water results in a marked decrease in the lipoperoxidative response as measured by the production of thiobarbituric acid reactive substances (TBARS) in mouse liver homogenates following acute dosing with TCA or dichloroacetic acid (DCA). Pretreatment with TCA or CFA also increased palmitoyl-CoA oxidase activity, microsomal 12-(ω) hydroxylation of lauric acid and expression of P450 4A isoforms. At the doses utilized, DCA-pretreatment did not increase the level of P450 4A protein, or markers of peroxisome proliferation. However, DCA-pretreatment did result in enhanced levels of TBARS, following acute dosing with DCA, compared to controls. Pretreatment with DCA, TCA, or CFA did not alter p-nitrophenol hydroxylation (an assay specific for P450 2E1), and no increases in immunodetectable P450 2E1, 4A, 1A1/2, 2B1/2 or 3A1 protein were observed. Assays from CFA- and TCA-pretreated mice suggest that the reduction in the TBARS response seen in TCA-pretreated animals results from activities associated with peroxisome proliferation. This might result from the induction of systems efficient in scavenging of peroxide intermediates or detoxification of aldehyde by-products of lipid peroxidation.
Keywords
Trichloroacetate; Dichloroacetate; Peroxisome proliferators; Lipid peroxidation
Tags
•
Tetrachloroethylene (Perc) (Final, 2012)
All References
Exposure
•
Trichloroacetic acid (TCA) (Final, 2011)
•
Trichloroethylene (TCE) (Final, 2011)
OPPT REs
•
OPPT_Perchloroethylene (Perc)_C. Engineering
Total – title/abstract screening
Off topic
•
OPPT_Perchloroethylene (Perc)_D. Exposure
Total – title/abstract screening
Off topic
•
OPPT_Perchloroethylene (Perc)_E. Fate
Total – title/abstract screening
Off topic
•
OPPT_Perchloroethylene (Perc)_F. Human Health
Total – title/abstract screening
Off topic
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